CONDENSATION POLYMERS FOR ANTIMICROBIAL APPLICATIONS

摘要

A number of cationic antimicrobial polymers have been synthesized by a condensation polymerization in bulk. The initial polymer formed has backbone tertiary nitrogens, which are subsequently quaternized using a suitable quaternizing agent (e.g., alkyl halide). The cationic polymers include polyamides, polycarbonates, polypolyureas and polyguanidiniums having a cationic repeat unit comprising the quaternary ammonium nitrogen as a backbone nitrogen. The cationic polymers can be active against Gram-negative, Gram-positive microbes, and/or fungi.

主权项

1. A cationic polymer, comprising:
i) a cationic repeat unit of formula (1):wherein
W′ is a single bond or a divalent linking group having a structure *—C(═O)-L′-*, wherein L′ is divalent radical comprising 1-20 carbons and L′ is linked to carbon 1, nitrogen labeled 2 is designated a tail and W′ is designated a head, La and Lb are independent divalent hydrocarbon groups comprising 2-20 carbons, and Q′ is a divalent radical selected from group consisting ofwherein Ra, Rb, Rc, Rd, Re are independent monovalent hydrocarbon groups comprising 1-20 carbons and each X− is an independent negative-charged counterion; and
ii) a polymeric repeat unit of formula (8):wherein
nitrogen labeled 2 is designated a tail, W″ is designated a head, W″ is a single bond or a divalent linking group having a structure *—C(═O)-L″-*, wherein L″ is divalent radical comprising 1-20 carbons and L″ is linked to carbonyl carbon 1, Lc and Ld are independent divalent linking groups selected from the group consisting of a single bond, and hydrocarbon groups comprising 1-6 carbons, and P′ is a divalent poly(alkylene oxide) chain;wherein
the cationic repeat unit and the polymeric repeat unit are covalently linked in a head-to-tail arrangement.