METHOD AND APPARATUS FOR MITIGATING ACUTE REOXYGENATION INJURY DURING PERCUTANEOUS CORONARY INTERVENTION

摘要

A system and methods are described for improving the management of ischemic cardiac tissue during acute coronary syndromes. The system combines a catheter-based sub-system which allows for simultaneous balloon dilation of a coronary artery and infusion of a carefully controlled perfusate during percutaneous coronary intervention. The system allows for modulation of levels of oxygen at the time of percutaneous intervention. In addition, catheters and systems are provided for administration of fluids with modified oxygen content during an intervention that incorporate upstream flow control members to compartmentalize the perfusion of the target coronary artery and the remainder of the heart.

主权项

1. A reperfusion system for use in treating a patient undergoing an interventional procedure in which a blood flow to a tissue has been reduced comprising:
a catheter having an occluding member; and an oxygenation controller in fluid communication with the catheter, the oxygenation controller comprising:
a pump for forcing a perfusate through the vascular perfusion catheter;a perfusate oxygenation modulator for controlling the oxygen level within the perfusate, anda controller configured to change the oxygenation level within the perfusate from a first oxygenation level to at least a second oxygenation level, the second oxygenation level being different from the first oxygenation level.