发明名称 USE OF ERIBULIN AND MTOR INHIBITORS AS COMBINATION THERAPY FOR THE TREATMENT OF CANCER
摘要 Methods for treating cancer (e.g., breast cancer, lung cancer, pancreatic cancer, primitive neuroectodermal tumors, lung cancer, ovarian cancer, endometrial cancer, pharyngeal cancer, esophageal cancer, and sarcoma) in a subject (such as an human patient) in need thereof by administering eribulin (e.g., eribulin mesylate, i.e., E7389, Halaven) in combination with one or more mammalian target of rapamycin (mTOR) inhibitors (e.g., everolimus, ridaforolimus, and temsirolimus), and kits therefor are provided.
申请公布号 US2017071903(A1) 申请公布日期 2017.03.16
申请号 US201515123476 申请日期 2015.03.02
申请人 Eisai R&D Management Co., Ltd. 发明人 FUNAHASHI Yasuhiro;Littlefield Bruce A.;UENAKA Toshimitsu
分类号 A61K31/357;A61K45/06;A61K31/436 主分类号 A61K31/357
代理机构 代理人
主权项 1. A method for treating a subject having or at risk of developing cancer, the method comprising administering to the subject (i) eribulin or a pharmaceutically acceptable salt thereof, and (ii) an inhibitor of mammalian target of rapamycin (mTOR) or a pharmaceutically acceptable salt, hydrate, solvate, or amorphous solid thereof.
地址 Tokyo JP