PROTECTING ORAL OVERDOSE WITH ABUSE DETERRENT IMMEDIATE RELEASE FORMULATIONS

摘要

The invention relates to a pharmaceutical dosage form which is particularly useful for the prevention of an overdose of the pharmacologically active ingredient contained therein after accidental or intentional simultaneous administration of a plurality of the dosage forms containing an overall supratherapeutic dose of the pharmacologically active ingredient.

主权项

1. A pharmaceutical dosage form comprising a pharmacologically active ingredient a and a polymer matrix which comprises a polyalkylene oxide having an average molecular weight of at least 200,000 g/mol; wherein at least a portion of the pharmacologically active ingredient a is contained in one or more particles A which comprise the polymer matrix in which the pharmacologically active ingredient a is embedded;
said dosage form being adapted to prevent an overdose of the pharmacologically active ingredient a after accidental or intentional simultaneous administration of a plurality of the dosage forms containing an overall supratherapeutic dose of the pharmacologically active ingredient a.