| 发明名称 |
NOVEL RNA SEQUENCE HAVING ANTI-TUMOUR ACTIVITY |
| 摘要 |
Provided is a novel useful microRNA having improved anti-tumour activity, obtained by introducing a variation in a microRNA which is present in-vivo and which exhibits an anti-tumour effect. This microRNA containing a base sequence (SEQ ID NO: 1) obtained by varying a predetermined region of the base sequence of miR-29b is able to exhibit a particularly outstanding anti-tumour effect. |
| 申请公布号 |
US2017073675(A1) |
申请公布日期 |
2017.03.16 |
| 申请号 |
US201515123623 |
申请日期 |
2015.03.04 |
| 申请人 |
YAMAMOTO Hirofumi;MORI Masaki |
发明人 |
YAMAMOTO Hirofumi;MORI Masaki;DOKI Yuichiro |
| 分类号 |
C12N15/113 |
主分类号 |
C12N15/113 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A microRNA, comprising a polynucleotide (i) or (ii):
(i) a polynucleotide having a base sequence represented by SEQ ID NO: 1; or (ii) a polynucleotide having a base sequence having a sequence identity of 70% or higher with the base sequence represented by SEQ ID NO: 1, and the polynucleotide having a comparable level of antitumor effect to the antitumor effect of the polynucleotide consisting of the base sequence represented by SEQ ID NO: 1. |
| 地址 |
Suita-shi, Osaka JP |
