CYANIDE ANTIDOTE COMPOSITIONS AND METHODS OF USE

摘要

Cyanide antidote compositions and methods of use are described herein. A cyanide antidote composition may include a sulfur analog, sulfur analog derivative, or a pharmaceutically acceptable derivative of a sulfur analog.

主权项

1. A method of treating cyanide intoxication in a subject, comprising:
administrating to a subject who would benefit from such treatment a therapeutically effective amount of a sulfur analog, or pharmaceutically acceptable derivative of a sulfur analog in an amount sufficient to convert at least some cyanide to thiocyanate to detoxify the subject, wherein the sulfur analog has the structure
R1—Sn—R2   (I) where R1 is S or R3—SO2—; R2 is R4—SO2— or R5; and n is 1 to 8; where R3 is an alkyl moiety or an aryl moiety; where R4 is an alkyl moiety or an aryl moiety; and R5 is an alkyl moiety or an aryl moiety.