COMPOSITIONS FOR RESPIRATORY DELIVERY OF ACTIVE AGENTS AND ASSOCIATED METHODS AND SYSTEMS

摘要

Compositions, methods and systems are provided for pulmonary or nasal delivery of active agents via a metered dose inhaler. In one embodiment, the compositions include a suspension medium, active agent particles, and suspending particles, in which the active agent particles and suspending particles form a co-suspension within the suspension medium.

主权项

1. A pharmaceutical composition deliverable from a metered dose inhaler, comprising:
a suspension medium comprising a pharmaceutically acceptable propellant; a first population of particles comprising active agent particles, wherein the active agent particles comprise respirable, micronized active agent; and a second population of particles comprising respirable suspending particles, wherein the respirable suspending particles are substantially insoluble in the suspension medium, and comprise a phospholipid; and wherein a weight ratio of total mass of respirable suspending particles to total mass of active agent particles ranges from 1:1 to about 200:1.