发明名称 |
Caprazol derivatives |
摘要 |
Caprazene and caprazol could be synthesized by hydrolysis of a caprazamycin. There could be synthesized a caprazene-1'''-amide derivative of the formula (II) <CHEM> and a caprazene-1'''-ester derivative of the formula (III) <CHEM> from caprazene. Further, there could be synthesized a caprazol-1'''-amide derivative of the formula (V) <CHEM> and a caprazol-1'''- amide-3'''-ester derivative and a caprazol-3'''-ester derivative, etc. from caprazol. Furthermore, an imidazolidinone derivative could be synthesized from the ring-opened product of the 1,4-diazepinone ring of caprazol. <??>The novel caprazene derivative, novel caprazol derivative and novel imidazolidinone derivative now synthesized exhibit excellent antibacterial activities against a variety of bacteria, including acid-fast bacteria. |
申请公布号 |
EP2527353(B1) |
申请公布日期 |
2017.03.15 |
申请号 |
EP20120180107 |
申请日期 |
2004.01.30 |
申请人 |
ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI;Meiji Seika Pharma Co., Ltd. |
发明人 |
Miyake, M. Toshiaki;Igarashi, M. Masayuki;Shitara, M. Tetsuo;Takahashi, M. Yoshiaki;Hamada, M. Masa |
分类号 |
C07H19/06;A61K31/7072;A61P31/04;A61P31/06;C07D403/08;C07D403/14;C07D405/14 |
主分类号 |
C07H19/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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