发明名称 |
25−ヒドロキシビタミンD3を含む経口剤形、及び、その経口剤形を週1回ヒトに投与することを含む方法 |
摘要 |
An oral dosage form comprising a single dose of 25-hydroxy-vitamin D3 sufficient to elevate the serum level in a human to a concentration in the range of 30 ng/ml to 200 ng/ml for at least 7 days and a pharmaceutically suitable oral carrier system, wherein subsequent single doses at least every 7 days are sufficient to sustain the serum level in a human to a concentration in the range of 30 ng/ml to 200 ng/ml at steady-state pharmacokinetics is disclosed. A method of elevating and sustaining the blood level concentration of 25-hydroxy-vitamin D3 in a human in need thereof comprising orally administering or parenterally administering by injection or infusion, at least once every 7 days, a single dose of 25-hydroxy-vitamin D3 sufficient to elevate the serum level in a human to a concentration in the range of 30 ng/ml to 200 ng/ml for at least 7 days, wherein the single doses orally administered at least every 7 days are sufficient to sustain the serum level in a human to a concentration in the range of 30 ng/ml to 200 ng/ml at steady-state pharmacokinetics is disclosed. The human in need thereof may be a human deficient in vitamin D having a serum level concentration of 25-hydroxy-vitamin D3 less than 30 ng/ml. |
申请公布号 |
JP6095891(B2) |
申请公布日期 |
2017.03.15 |
申请号 |
JP20110520222 |
申请日期 |
2009.07.24 |
申请人 |
ウイスコンシン アラムナイ リサーチ ファウンデーシヨンWISCONSIN ALUMNI RESEARCH FOUNDATION |
发明人 |
デルカ、ヘクター、エフ;プラム、ロリ、エイ;クラゲット−デイム、マーガレット |
分类号 |
A61K31/593;A61K9/08;A61K9/20;A61K9/48;A61K31/592;A61P3/02 |
主分类号 |
A61K31/593 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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