摘要 |
Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula ( I ):
or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula ( IA ) are as described herein. A compound is represented by Structural Formula ( IA ) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula ( IA ) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle. |
申请人 |
Vertex Pharmaceuticals Inc. |
发明人 |
CHARIFSON, Paul;CLARK, Michael, P.;BANDARAGE, Upul, K.;BETHIEL, Randy, S.;COURT, John, J.;DENG, Hongbo;DRUTU, Ioana;DUFFY, John, P.;FARMER, Luc;GAO, Huai;GU, Wenxin;JACOBS, Dylan, H.;KENNEDY, Joseph, M.;LEDEBOER, Mark, W.;LEDFORD, Brian;MALTAIS, Francois;PEROLA, Emanuele;WANG, Tiansheng;WANNAMAKER, M., Woods;BYRN, Randal;ZHOU, Yi;LIN, Chao;JIANG, Min;GERMANN, Ursula, A.;JONES, Steven;SALITURO, Francesco G.;KWONG, Ann Dak-Yee |