发明名称 |
NOVEL GLP-1 RECEPTOR STABILIZERS AND MODULATORS |
摘要 |
Compounds that bind the glucagon-like peptide 1 (GLP-1) receptor, methods of their synthesis, methods of their therapeutic and/or prophylactic use, and methods of their use in stabilizing GLP-1 receptor in vitro for crystallization of the GLP-1 receptor are provided. Certain compounds may have activity as modulators or potentiators with respect to glucagon receptor, GIP receptor, GLP-1 and GLP-2 receptors, and PTH receptor on their own or in the presence of receptor ligands such as GIP(1-42), PTH(1-34), Glucagon(1-29), GLP-2(1-33), GLP-1 (7-36), GLP-1 (9-36), oxyntomodulin and exendin variants. |
申请公布号 |
EP2713722(B1) |
申请公布日期 |
2017.03.15 |
申请号 |
EP20120793320 |
申请日期 |
2012.05.31 |
申请人 |
Receptos, LLC |
发明人 |
BOEHM, Marcus, F.;MARTINBOROUGH, Esther;MOORJANI, Manisha;TAMIYA, Junko;HUANG, Liming;FOWLER, Thomas;NOVAK, Andrew;MEGHANI, Premji;BRAHMACHARY, Enugurthi;YEAGER, Adam, Richard |
分类号 |
C07D213/80;C07D213/79;C07D213/81;C07D213/82;C07D309/06;C07D311/16 |
主分类号 |
C07D213/80 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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