| 发明名称 |
PREVENTION AND TREATMENT OF ALZHEIMER'S DISEASE BY GENOME EDITING USING THE CRISPR/CAS SYSTEM |
| 摘要 |
Methods and products related to genome editing using the CRISPR/Cas9 system to introduce an A673T substitution into an APP gene, such as guide RNAs and recombinant proteins, are described for decreasing APP levels produced by a cell, and use for the treatment of Alzheimer's disease and/or age-related cognitive decline in a cell from a subject in need thereof. |
| 申请公布号 |
EP3140403(A1) |
申请公布日期 |
2017.03.15 |
| 申请号 |
EP20150789631 |
申请日期 |
2015.05.08 |
| 申请人 |
Université Laval |
发明人 |
TREMBLAY, Jacques P.;ROUSSEAU, Joël;CHAPDELAINE, Pierre |
| 分类号 |
C12N15/63;A61K48/00;A61P25/28;C12N15/09;C12N15/113;C12N15/12;C12N15/55;C12N15/85;C12N15/86;C12N15/90 |
主分类号 |
C12N15/63 |
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