发明名称 |
ERBB2 SIGNALING AND NERVE REGENERATION |
摘要 |
Use of an inhibitor of the ErbB2 receptor for treatment or repair of nerves and/or nerve tissues is provided. The inhibitor includes an antibody, in particular, a monoclonal antibody, for example, Herceptin. A medicament for treatment or repair of nerves and/or nerve tissues can be formulated which includes an inhibitor of the ErbB2 receptor. A pharmaceutical kit may include a medicament having an inhibitor of the ErbB2 receptor and dosing instructions for administrating the medicament for treatment or repair of nerves and/or nerve tissues. Also provided are uses of an inhibitor of the ErbB2 receptor for increasing axon regeneration, preventing neuron or glial cell death, and/or stimulating Schwann cell proliferation in a nerve stump. |
申请公布号 |
EP3137110(A1) |
申请公布日期 |
2017.03.08 |
申请号 |
EP20150786559 |
申请日期 |
2015.05.04 |
申请人 |
The Hospital For Sick Children |
发明人 |
HENDRY, James M.;PLACHETA, Eva;GORDON, Tessa;BORSCHEL, Gregory H. |
分类号 |
A61K39/395;A61P25/00 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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