发明名称 |
COMBINATION OF A PHOSPHATIDYLINOSITOL-3-KINASE (PI3K) INHIBITOR AND A MTOR INHIBITOR. |
摘要 |
The invention relates to a pharmaceutical combination which comprises (a) a phosphoinositide 3-kinase inhibitor compound of formula (I) and (b) a mTOR inhibitor for the treatment of a target of rapamycin (mTOR) kinase dependent disease, especially a cancer disease; a pharmaceutical composition comprising such a combination; the use of such a combination for the preparation of a medicament for the treatment of a proliferative disease; a commercial package or product comprising such a combination as a combined preparation for simultaneous, separate or sequential use; and to a method of treatment of a warm-blooded animal, especially a human. |
申请公布号 |
EP2349275(B1) |
申请公布日期 |
2017.03.08 |
申请号 |
EP20090744391 |
申请日期 |
2009.10.29 |
申请人 |
Novartis AG |
发明人 |
GARCIA-ECHEVERRIA, Carlos;MAIRA, Sauveur-Michel |
分类号 |
A61K31/5377;A61K31/436;A61K45/06;A61P35/00 |
主分类号 |
A61K31/5377 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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