METHOD FOR ASSESSING AUTOIMMUNE ARTHRITIS, AND SCREENING METHOD FOR SUBSTANCES INHIBITING ACTIVITY OF AUTOIMMUNE ARTHRITIS-INDUCING T CELLS

摘要

Provided are a method for identifying the presence or likelihood of autoimmune arthritis, the method comprising detecting (1) an anti-ribosomal protein L23a antibody or (2) ribosomal protein L23a-reactive CD4 + T cells in a sample derived from a subject; and a method for screening for a substance that inhibits the activation of autoimmune arthritogenic T cells, the method comprising the steps of bringing a test substance into contact with ribosomal protein L23a-reactive T cells, bringing the T cells into contact with ribosomal protein L23a or a fragment thereof, measuring the level of a proinflammatory cytokine secreted from the T cells, and analyzing the test substance-dependent change in the secretion level of the proinflammatory cytokine.