发明名称 |
Enzyme catalyzed therapeutic agents |
摘要 |
This invention provides a method for identifying potential therapeutic agents by contacting a target cell with a candidate therapeutic agent which is a selective substrate for an endogenous, intracellular enzyme in the cell which is enhanced in its expression as a result of selection by biologic or chemotherapy. This invention also provides methods and examples of molecules for selectively killing a pathological cell by contacting the cell with a prodrug that is a selective substrate for an endogenous, intracellular enzyme. The prodrug is subsequently converted to a cellular toxin. Further provided by this invention is a method for treating a pathology characterized by pathological, hyperproliferative cells in a subject by administering to the subject a prodrug that is a selective substrate for an endogenous, overexpressed, intracellular enzyme, and converted by the enzyme to a cellular toxin in the hyperproliferative cell. |
申请公布号 |
EP1167972(B1) |
申请公布日期 |
2017.03.08 |
申请号 |
EP20010120242 |
申请日期 |
1999.01.22 |
申请人 |
Kiadis Pharma Intellectual Property B.V. |
发明人 |
Shepard, Michael H.;Groziak, Michael P. |
分类号 |
C07H19/073;G01N33/50;A61K31/664;A61K31/7042;A61K31/7052;A61K31/7056;A61K31/7064;A61K31/7072;A61K45/00;A61K47/48;A61K51/00;A61P35/00;A61P43/00;C07F9/6512;C07H19/04;C07H19/044;C07H19/06;C07H19/10;C07H19/20;C12N5/00;C12N5/18;C12Q1/00;C12Q1/02;C12Q1/25 |
主分类号 |
C07H19/073 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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