发明名称 |
PROCESS FOR THE SYNTHESIS OF EZETIMIBE AND INTERMEDIATES USEFUL THEREFORE |
摘要 |
The present invention discloses novel and useful intermediates for the synthesis of ezetimibe (EZT), which intermediates share a characteristic Z -isomeric structure. Based on Z -5-(4-fluorophenyl)-pent-4-enoic acid, and proceeding the synthesis through further Z- intermediates, a total synthesis is presented to obtained final ezetimibe in high yields. |
申请公布号 |
EP2326616(B1) |
申请公布日期 |
2017.03.08 |
申请号 |
EP20090781241 |
申请日期 |
2009.07.29 |
申请人 |
LEK Pharmaceuticals d.d. |
发明人 |
MRAVLJAK, Janez;SOVA, Matej;KOVAC, Andreja;GOBEC, Stanislav;CASAR, Zdenko |
分类号 |
C07C57/60;C07C51/09;C07C67/343;C07C69/65;C07D205/08;C07D263/26 |
主分类号 |
C07C57/60 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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