The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise analyzing at least one plasma sample from the subject to determine a value of the subject's lipidomic profile, and also analyzing the gene expression profile from leukocytes and comparing the value of the subject's biomarker profile (lipidomic profile plus gene expression profile) with the value of a normal biomarker profile. A change in the value of the subject's biomarker profile, including a change in the subject's biomarker profile, over normal values is indicative that the subject has an increased risk of suffering from memory impairment compared to a normal individual.
申请公布号
EP3137900(A1)
申请公布日期
2017.03.08
申请号
EP20150785913
申请日期
2015.04.30
申请人
Georgetown University;University of Rochester
发明人
FEDEROFF, Howard, J.;MAPSTONE, Mark, E.;CHEEMA, Amrita, K.;FIANDACA, Massimo, S.