发明名称 MUTATED IMMUNOGLOBULIN-BINDING POLYPEPTIDES
摘要 The invention discloses a polypeptide with improved alkaline stability, which polypeptide comprises a mutant of a B or C domain of Staphylococcus Protein A (SpA), as specified by SEQ ID NO 1 or SEQ ID NO 2, or of Protein Z, as specified by SEQ ID NO 3, comprising at least the mutation wherein the glutamine residue at position 9 has been mutated to a tryptophan, leucine, glutamic acid, valine or lysine. The invention also discloses multimers of the polypeptide, as well as separation matrices comprising the multimers or polypeptides.
申请公布号 EP3019520(A4) 申请公布日期 2017.03.08
申请号 EP20140823829 申请日期 2014.07.08
申请人 GE Healthcare Bio-Sciences AB 发明人 RODRIGO, Gustav;ANDER, Mats;BAURÉN, Göran;BJÖRKMAN, Tomas
分类号 C07K14/31;B01D15/38;C07K1/22;C12N15/00 主分类号 C07K14/31
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