Controlled release dosage form

摘要

The present invention provides a simple and improved dose form that is capable of providing a controlled release of GABAB receptor agonist contained in the core thereof. The invention also provides methods of administering the dosage form and of treating conditions that are therapeutically responsive to GABAB receptor agonist.

主权项

1. A controlled release oral dosage form comprising:
a) a core comprising at least one GABAB receptor agonist and at least two water-swellable excipients; and b) a semipermeable membrane surrounding the core, said membrane comprising at least two film-forming cellulose esters and at least one preformed passageway; wherein the at least one GABAB receptor agonist is (R)-baclofen (ARBAC); and following oral administration of said dosage form, the dosage form releases a majority of ARBAC downstream of the stomach and upstream of the colon.