Palatable liquid dilution vehicles for oral contrast agents

摘要

The invention relates to liquid vehicles that can be used to create dilute solutions of water-soluble pharmaceutical or non-pharmaceutical oral contrast agents. The liquid vehicles are formulated to provide desired osmolalities, viscosities, pH, and taste masking capabilities to match the particular intentions of the user and to complement the inherent differences in the various oral contrast agents. The liquid vehicles comprise an aqueous medium, an osmotic agent to adjust osmolality, a buffering agent, a viscosity agent, and sweeteners and flavoring agents to improve palatability.

主权项

1. A liquid vehicle for preparation of solutions containing water-soluble oral contrast agents for administration for gastrointestinal tract opacification prior to computed tomography imaging, magnetic resonance imaging, or conventional radiographic imaging to obtain desired imaging characteristics, said liquid vehicle comprising:
Sodium Hexametaphosphate—about 1 gm; Sodium Benzoate—about 0.15 gm; Potassium Sorbate—about 0.1 gm; Calcium Disodium—about EDTA 0.033 gm; Sucralose—about 0.145 gm; Acesulfame Potassium—about 0.11 gm; Sorbitol—about 2.5 gm; Mannitol—about 0.5 gm; Citric Acid 1 about 2.13 gm; Sodium Citrate—about 0.90 gm; Malic Acid—about 0.32 gm; one or more Liquid Flavors—about 1.525 ml; and Sufficient water to achieve 1 Liter total volume.