Isothiocyanate compounds, pharmaceutical compositions, and uses thereof

摘要

Provided herein are compositions of matter and pharmaceutical compositions thereof, for use in inhibiting the growth of various microbial pathogens, including bacteria, fungi, protozoa, and viral pathogens. Also provided herein are methods of treating microbial diseases/infections and cancer with the compositions. The compositions are additionally useful in wood preservation and food preservation by inhibition of microbial growth.

主权项

1. A composition of matter according to Formula I:
S═C═N—(R)b—(X)a—(R)c—N═C═S or a pharmaceutically acceptable salt or thereof, wherein:a is 1, b is 1, and c is 0 or 1;
X is an aryl or heteroaryl ring system which may be unsubstituted or substituted with from 1 to 4 moieties selected from —Br, —Cl, —OH, —NH2, —COOH, OR′—CH3 or R″—CH3 wherein R′ and R″, independently, are an alkylene moiety having the formula —(CH2)n—, where n can be an integer from 0 to 20; and each R, independently, is selected from the group consisting of linear or branched alkylene moieties having from 1 to 20 C atoms; linear or branched alkenylene and alkynylene moieties having from 2 to 20 C atoms; linear or branched heteroalkylene moieties having from 2 to 20 C atoms and from 1 to 3 O, N or S atoms; and heteroarylene, and cycloalkylene moieties having from 5 to 10 C atoms and from 1 to 3 N, S, or O atoms; provided that R is not —CH2— when X is phenyl.