| 主权项 |
1. A method for inhibiting breast cancer tumor growth in a human being diagnosed with breast cancer, wherein said breast cancer shows expression of CD44v6, comprising administering a compound to the human being in need thereof, wherein said compound comprises:
(i) a peptide comprising at least the amino acid sequence X1-R-W-H-X5 (SEQ ID NO: 1) with X1 being an amino acid selected from the group consisting of A, C, D, E, F, G, H, I, K, L, M, N, P, Q, R, S, T, V, W, and Y and X5 being an amino acid selected from the group consisting of A, C, D, E, F, G, H, I, K, L, M, N, P, Q, R, S, T, V, W, and Y, or a peptidomimetic thereof, or (ii) a peptide comprising at least 5, 6, 7, 8, 9, 10, 11, 12, 13, or 14 amino acids of amino acid sequence X1-X2-X3-X4-X5-X6-X7-R-W-H-X11-X12-X13-X14 (SEQ ID NO: 7), wherein X1, X2, X3, X4, X5, X6, X7, X11, X12, X13, or X14 is an amino acid selected from the group consisting of A, C, D, E, F, G, H, I, K, L, M, N, P, Q, R, S, T, V, W, and Y, and wherein the peptide comprises at least X7-R-W-H-X11 of SEQ ID NO: 7, wherein X7 and X11 is an amino acid selected from the group consisting of A, C, D, E, F, G, H, I, K, L, M, N, P, Q, R, S, T, V, W, and Y, or a peptidomimetic thereof. |
