发明名称 |
BENZOIC ACID (1-PHENYL-2-PYRIDIN-4-YL) ETHYL ESTERS AS PHOSPHODIESTERASE INHIBITORS |
摘要 |
The present invention relates to inhibitors of the phosphodiesterase 4 (PDE4) enzyme. More particularly, the invention relates to compounds that are derivative of -phenyl -2-pyridinyl alkyl alcohols, methods of preparing such compounds, compositions comprising them, combinations and therapeutic uses thereof (I) wherein n is O or 1; R1 and R2 may be the same or different, and are selected from the group consisting of: - linear or branched C1-C6 alkyl; - OR3 wherein R3 is C1-C6 alkyl optionally substituted by one or more C3-C7 cycloalkyl groups; and - HNSO2R4 wherein R4 is C1-C4 alkyl optionally substituted with one or more halogen atoms or with a C1-C4 group, wherein at least one of R1 and R2 is HNSO2R4. The other variables are as defined in the claims. |
申请公布号 |
CA2751494(C) |
申请公布日期 |
2017.03.07 |
申请号 |
CA20102751494 |
申请日期 |
2010.02.04 |
申请人 |
CHIESI FARMACEUTICI S.P.A. |
发明人 |
AMARI, GABRIELE;ARMANI, ELISABETTA;DELCANALE, MAURIZIO |
分类号 |
C07D213/61;A61K31/44;A61P11/00;C07D213/89 |
主分类号 |
C07D213/61 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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