发明名称 |
MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS |
摘要 |
A compound of formula (I): (see formula I) or a pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising a compound according to formula (I) and a pharmaceutically acceptable carrier, a kit for use in measuring the activity of an ABC transporter or a fragment thereof in a biological sample in vitro or in vivo, comprising a composition comprising the compound of formula (I) and instructions for a) contacting the composition with the biological sample and b) measuring activity of said ABC transporter or a fragment thereof, and use of an effective amount of the compound of formula (I) or the pharmaceutically acceptable salt thereof for treating or lessening the severity of a disease in a patient need thereof. |
申请公布号 |
CA2856037(C) |
申请公布日期 |
2017.03.07 |
申请号 |
CA20062856037 |
申请日期 |
2006.12.28 |
申请人 |
VERTEX PHARMACEUTICALS INCORPORATED |
发明人 |
RUAH, SARA S. HADIDA;MILLER, MARK T.;BEAR, BRIAN;MCCARTNEY, JASON;GROOTENHUIS, PETER D.J. |
分类号 |
C07C237/24;A61K31/00;C07C311/46;C07D207/12;C07D307/79;C07D317/60;C07D319/18;C07D405/12;C07D409/12;C07D413/12;C07D498/04 |
主分类号 |
C07C237/24 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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