IgE antibodies for the inhibition of tumor metastasis

摘要

The present invention provides novel IgE antibodies useful for inhibiting or preventing metastatic cancer. Also provided are methods to inhibit tumor metastasis by modulating the activity of at least one non-tumor cell, treating a patient to inhibit or prevent tumor metastases of a primary solid tumor, treating metastatic carcinoma, reducing metastasis of carcinoma cells, and reducing the growth kinetics of a primary solid tumor or a metastasized cell or tumor.

主权项

1. An IgE monoclonal antibody that specifically binds an epitope of MUC1 and is capable of modulating immune effector cells to inhibit tumor metastasis having a heavy chain variable region encoded by a nucleic acid comprising CDRs 1-3 of a heavy chain variable region encoded by SEQ ID NO: 1 and a light chain variable region encoded by a nucleic acid comprising CDRs 1-3 of a light chain variable region encoded by SEQ ID NO: 2, optionally humanized.