Leucocyte removal filter

摘要

The present invention aims to provide a leukocyte depletion filter that has both higher leukocyte removal performance and higher blood permeability than conventional filters. The leukocyte depletion filter according to the present invention includes a filter material having an average fiber diameter of 0.30 to 1.60 μm and a coefficient of variation of fiber diameter of at least 0.40 but not more than 1.20.

主权项

1. A leukocyte depletion filter, comprising:
a receptacle having fluid inlet and outlet; a first leukocyte depletion filter material packed in the receptacle, the first leukocyte depletion filter material comprising fibers that have an average fiber diameter of 0.50 to 1.60 μm and a coefficient of variation of fiber diameter of 0.40 to 0.80, an average pore size of 4.0 to 8.0 μm, and a bulk density of 0.10 to 0.35 g/cm3; and a second leukocyte depletion filter material located upstream of the first leukocyte depletion filter material, the second leukocyte depletion filter material comprising fibers that have an average fiber diameter of 1.20 to 3.00 μm, wherein the average fiber diameter of the fibers of the second leukocyte depletion filter material is greater than the average fiber diameter of the fibers of the first leukocyte depletion filter material, and the first and second leukocyte depletion filter materials satisfy the following formulas (a) and (b):
|A−B|≦0.21  (a)0.15≦A×B≦0.33  (b) where A represents the coefficient of variation of fiber diameter of the fibers in the first leukocyte depletion filter material, and B represents a coefficient of variation of fiber diameter of the fibers in the second leukocyte depletion filter material.