Adenosine receptor agonists and antagonists to modulate T cell responses

摘要

Described are uses of A2a adenosine receptor antagonists and agonists to provide long term modulation of immune responses. A2a receptor antagonists in particular are provided to enhance immune responses by reducing T-cell mediated tolerance to antigenic stimuli and agonists are provided to enhance effectiveness of immunosuppressive agents. The application provides methods of treatment and prevention based on the long term effects of the compounds on T cell responses.

主权项

1. A method of treating or preventing abnormal cell proliferation in a host, comprising administering to said host an A2a receptor antagonist in combination or alternation with a mammalian cell based vaccine, wherein the mammalian cell is genetically modified.