Longevity of hyperpolarized enhanced signals for ¹H NMR spectroscopy

摘要

A method and system for providing an article of manufacture with increased longevity of hyperpolarized 1H signals (and other species) for NMR spectroscopy and MRI. The method involves providing a material including a molecular species susceptible of NMR spectroscopy, by providing parahydrogen (and other appropriate species) to disperse within the material/solvent to establish increased longevity of the NMR signals. The material can be in a solution with a surfactant and catalysts added to enhance the persistence of parahydrogen (or other species) in the form of enhanced solubility, microbubbles or micelles and resultant hydrogenation (or other species) of the material.

主权项

1. A system comprising:
a source of hyperpolarization material; a reaction vessel for converting the hyperpolarization material from an ortho spin state to a para spin state; and an injection system for dispersing the hyperpolarization material into a sample container having a surfactant and a hyperpolarizable NMR material; wherein the para-hyperpolarization material hyperpolarizes the NMR material.