摘要 |
The present invention relates to a compound of Formula 1, 2 or 3: wherein A is N or CR0 --, where R0 is hydrogen, C1 -C6 linear or branched chain alkyl, etc., Z is CRe --, or, N--, where Re is hydrogen, C1 -C6 linear or branched chain alkyl,etc.; R1 is hydrogen, C1 -C6 linear or branched chain alkyl, etc.; R2 are independently hydrogen or C1 -C6 linear or branched chain alkyl; R3 and R4 are independently hydrogen, C1 -C6 linear or branched chain alkyl, etc.;. R5 and R6 are independently hydrogen or C1 -C6 linear or branched chain alkyl, etc.; R8 is hydrogen, C1 -C6 linear or branched chain alkyl, etc.; R9 and R10 are independently hydrogen or C1 -C6 linear or branched chain alkyl, etc.; Q is --CO--, --(CH2 )q --, --(CHRS )q --, or (CRS Rt )q--, where RS and Rt are independently C1 -C6 linear or branched chain alkyl, aryl, alkylaryl, heteroaryl or alkylheteroaryl; where q is 0, 1, 2, or 3; and, where n is 0, 2, 3, 4 or 5; or, a pharmaceutically acceptable salt thereof, to compositions containing such compounds; and to the uses of such compounds in the treatment of various diseases, particularly, those affected or mediated by the androgen receptor. |
申请人 |
PFIZER INC. |
发明人 |
ANDERSON, JAMES THOMAS;CHEKLER, EUGENE LVOVICH PIATNITSKI;ELLSWORTH, EDMUND L.;ERICKSON, BRUCE KIPP;GILBERT, ADAM MATTHEW;RICKETTS, ANTHONY P.;THOMPSON, DAVID P.;UNWALLA, RAYOMAND JAL;VERHOEST, PATRICK ROBERT |