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1. A pharmaceutical composition comprising an isolated humanized affinity-matured monoclonal antibody capable of binding human CCR4 having
a. a heavy chain with three CDRs comprising a CDR 1 comprising amino acid sequence GYTFASQW (SEQ ID NO:22), a CDR 2 comprising amino acid sequence INPGNVNT (SEQ ID NO:27), and a CDR 3 comprising amino sequence STWYRPLDY (SEQ ID NO:30) and a light chain with three CDRs comprising a CDR 1 comprising amino acid sequence QSILYSSNQKNY (SEQ ID NO:26), a CDR 2 comprising amino acid sequence WASTRE (SEQ ID NO:28), and a CDR 3 comprising amino acid sequence HQYISSYT (SEQ ID NO:35); b. a heavy chain with three CDRs comprising a CDR 1 comprising amino acid sequence GYTFASSW (SEQ ID NO:23), a CDR 2 comprising amino acid sequence INPGNVNT (SEQ ID NO:27), and a CDR 3 comprising amino sequence STWYRPNDY (SEQ ID NO:31) and a light chain with three CDRs comprising a CDR 1 comprising amino acid sequence QSILYSSNQKNY (SEQ ID NO:26), a CDR 2 comprising amino acid sequence WASTRE (SEQ ID NO:28), and a CDR 3 comprising amino sequence HQYKSSYT (SEQ ID NO:36); c. a heavy chain with three CDRs comprising a CDR 1 comprising amino acid sequence GYTFASSW (SEQ ID NO:23), a CDR 2 comprising amino acid sequence INPGNVNT (SEQ ID NO:27), and a CDR 3 comprising amino sequence TTRYRPLDY (SEQ ID NO:32) and a light chain with three CDRs comprising a CDR 1 comprising amino acid sequence QSILYSSNQKNY (SEQ ID NO:26), a CDR 2 comprising amino acid sequence WASTRE (SEQ ID NO:28), and a CDR 3 comprising amino sequence HQYRSSYT (SEQ ID NO:37); d. a heavy chain with three CDRs comprising a CDR 1 comprising amino acid sequence GYTFASQY (SEQ ID NO:24), a CDR 2 comprising amino acid sequence INPGNVNT (SEQ ID NO:27), and a CDR 3 comprising amino acid sequence LTYYRPPDY (SEQ ID NO:33) and a light chain with three CDRs comprising a CDR 1 comprising amino acid sequence QSILYSSNQKNY (SEQ ID NO:26), a CDR 2 comprising amino acid sequence WASTRE (SEQ ID NO:28), and a CDR 3 comprising amino acid sequence HQYYSSYT (SEQ ID NO:38); or e. a heavy chain with three CDRs comprising a CDR 1 comprising amino acid sequence GYTFASAW (SEQ ID NO:25), a CDR 2 comprising amino acid sequence INPGNVNT (SEQ ID NO:27), and a CDR 3 comprising amino acid sequence STYYRPLDY (SEQ ID NO:29) and a light chain with three CDRs comprising a CDR 1 comprising amino acid sequence QSILYSSNQKNY (SEQ ID NO:26), a CDR 2 comprising amino acid sequence WASTRE (SEQ ID NO:28), and a CDR 3 comprising amino acid sequence HQYMSSYT (SEQ ID NO:39). |