Nicotine-containing product

摘要

A nicotine-containing product comprising a pharmaceutically acceptable polymeric substrate, which is able to bind cations, nicotine or a pharmaceutically acceptable nicotine derivative, and pharmaceutically acceptable inorganic cations. It further pertains to a method for the preparation of such a nicotine-containing product and to the use thereof for the preparation of a pharmaceutical product.

主权项

1. A method for producing a nicotine-containing product, comprising steps of:
(a) pre-treating a pharmaceutically acceptable polymeric substrate with a pharmaceutically acceptable inorganic or organic salt having an inorganic cation in the presence of a solvent at a temperature of 10-30° C. for a period of 5-60 min; (b) treating the pre-treated substrate of step (a) with nicotine or a pharmaceutically acceptable nicotine salt at a temperature of 10-30° C. for 5-60 min; and (c) removing the solvent, wherein: the pharmaceutically acceptable polymeric substrate is Amberlite® IRP-64 or betadex; and the pharmaceutically acceptable inorganic or organic salt having an inorganic cation is Ca(OH)2.