Nuclear transport modulators and uses thereof

摘要

The present invention relates to compounds of formula I:;
and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising the compounds of formula I, and methods of using the compounds, salts and compositions in the treatment of various disorders associated with CRM1 activity.

主权项

1. A method for treating a disorder associated with CRM1 activity, comprising administering to a subject in need thereof a therapeutically effective amount of a compound represented by structural formula I: or a pharmaceutically acceptable salt thereof, wherein:
R1 is selected from hydrogen and C1-C4 alkyl;R2 is selected from O and S; andR3 is selected from —N(R4)—(C3-C6 cycloalkyl), —C1-C6 alkyl, —(C0-C4 alkylene)-heterocyclyl, and —(C0-C4 alkylene)-heteroaryl, wherein any alkyl, alkylene, heterocyclyl, and heteroaryl portion of R3 is optionally and independently substituted; andR4 is selected from hydrogen and C1-C4 alkyl, and wherein, the disorder is selected from lupus, multiple sclerosis, amyotrophic lateral sclerosis and rheumatoid arthritis.