Polymeric structures containing strained cycloalkyne functionality for post-fabrication azidealkyne cycloaddition functionalization

摘要

A method of creating biocompatible polymeric structures includes the steps of: providing a biocompatible polymer including a strained cycloalkyne end group; forming a polymeric structure from the biocompatible polymer such that the strained cycloalkyne end group remains on the biocompatible polymer; providing an azide tethered molecule; and, after forming the polymeric structure, reacting the azide tethered molecule with the cycloalkyne in an azide alkyne cycloaddition reaction to further functionalize the polymeric structure.

主权项

1. A method of constructing biocompatible polymeric structures comprising the steps of:
preparing a biocompatible polymer including a strained cycloalkyne end group by ring-opening polymerization of one or more monomers employing a ROP initiator having a strained cycloalkyne; forming a polymeric structure from the biocompatible polymer such that the strained cycloalkyne end group remains on the biocompatible polymer; providing an azide tethered molecule; and, after said step of forming, reacting the azide tethered molecule with the cycloalkyne in an azide alkyne cycloaddition reaction to further functionalize the polymeric structure.