主权项 |
1. A compound according to Formula (I):or a salt thereof, wherein:
R2 and R4 are different and independently are each phenyl substituted with one or more of the same or different R8 groups; R5 is fluoro; R8 is selected from Ra, Rb, Ra substituted with one or more of the same or different Ra or Rb, ORa substituted with one or more of the same or different Ra, —(CH2)m—Rb, —(CHRa)m—Rb, —O—(CH2)m—Rb, —O—(CHRa)m—Rb, —C(O)NH—(CH2)m—Rb, —C(O)NH—(CHRa)m—Rb, —O—(CH2)m—C(O)NH—(CH2)m—Rb—O—(CHRa)m—C(O)NH—(CHRa)m—Rb, —NH—(CH2)m—Rb—NH—(CHRa)m—Rb; each Ra is independently selected from (C1-C6) alkyl, (C3-C8) cycloalkyl, cyclohexyl, (C4-C11) cycloalkylalkyl, (C5-C10) aryl, phenyl, (C6-C16) arylalkyl, benzyl, 3-8 membered cycloheteroalkyl, morpholinyl, piperazinyl, homopiperazinyl, piperidinyl, 4-11 membered cycloheteroalkylalkyl, 5-10 membered heteroaryl, or 6-16 membered heteroarylalkyl; each Rb is independently selected from ORa, (C1-C3) haloalkyloxy, —NRcRc, halogen, —CF3, —CN, —OCN, —SCN, —NO, NO2, —N3, —S(O)Ra, —S(O)2Ra, —S(O)2ORa, —S(O)2NRcRc, —OS(O)Ra, —OS(O)2Ra, —OS(O)2ORa, —OS(O)2NRcRc, —C(O)Ra, —C(O)ORa, —C(O)NRcRc, —C(NH)NRcRc, OC(O)Ra, —OC(O)ORa, —OC(O)NRcRc, —OC(NH)NRcRc, —[NHC(O)]Ra, —[NHC(O)]ORa, —[NHC(O)]NRcRc or —[NHC(NH)]NRcRc; each Rc is independently H or Ra; at least one R8 is Rb; and each m is independently an integer from 1 to 3. |