TDP-43 specific binding molecules

摘要

Provided are novel TAR DNA-binding proteins of 43 kDa (“TDP-43”)-specific binding molecules including polypeptides such as human antibodies, as well as fragments, derivatives and variants thereof. Also provided are methods related to these TDP-43 specific binding molecules. Assays, kits, and solid supports related to TDP-43-specific binding molecules, including polypeptides such as, human antibodies are also disclosed. The TDP-43-specific binding molecule, antibody, immunoglobulin chain(s), as well as binding fragments, derivatives and variants thereof can be used in pharmaceutical and diagnostic compositions for TDP-43 targeted immunotherapy and diagnosis, respectively.

主权项

1. A method of reducing the accumulation of pathological TDP-43 deposits or reducing pathological TAR-DNA-binding protein 43 kDa (TDP-43) distribution in a human subject in need thereof, comprising administering to the subject an effective amount of an anti-TDP-43 monoclonal antibody comprising a heavy chain variable (VH) region comprising the amino acid sequences of SEQ ID NO:131 (VH CDR1), SEQ ID NO:132 (VH CDR2), and SEQ ID NO:133 (VH CDR3) and a light chain variable (VL) region comprising the amino acid sequences of SEQ ID NO:135 (VL CDR1), SEQ ID NO:136 (VL CDR2), and SEQ ID NO:137 (VL CDR3).