| 发明名称 |
Live attenuated chimeric porcine circovirus vaccine |
| 摘要 |
The present invention provides a novel chimeric porcine circovirus infectious DNA clone and live attenuated chimeric virus with the PCV2, preferably of subtype PCV2b, capsid gene integrated into a non-pathogenic PCV1 virus genome. In a particular embodiment, the PCV2 capids gene is of subtype PCV2b, the predominant subtype circulating in pigs worldwide. The attenuated chimeric virus, designated PCV1-2b, effectively protects pigs from PCV2b challenges, and can be used as a live vaccine, as well as an inactivated (killed) vaccine, that provides protection and cross protection against PCV2b and PCV2a subtypes infection. The live attenuated vaccine of the present invention is also effective protecting pigs from porcine circovirus-associated disease (PCVAD). |
| 申请公布号 |
US9585951(B2) |
申请公布日期 |
2017.03.07 |
| 申请号 |
US201113049364 |
申请日期 |
2011.03.16 |
| 申请人 |
VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. |
发明人 |
Meng Xiang-Jin;Beach Nathan M.;Ramamoorthy Sheela |
| 分类号 |
A61K39/12;C12N7/00;C12N15/63;A61P31/12;A61P31/20;A61K39/00 |
主分类号 |
A61K39/12 |
| 代理机构 |
|
代理人 |
Rosenblum Anne M. |
| 主权项 |
1. A chimeric PCV1-2b virus comprising a recombinant PCV1 that encodes the capsid protein of PCV2b subtype in place of the capsid protein of PCV1, wherein the capsid protein of the PCV2b subtype is encoded by the ORF2 capsid gene of a wild-type PCV2b strain having the full-length genomic nucleotide sequence set forth in SEQ ID NO: 2. |
| 地址 |
Blacksburg VA US |
