| 发明名称 |
CAMELID SINGLE-DOMAIN ANTIBODY DIRECTED AGAINST PHOSPHORYLATED TAU PROTEINS AND METHODS FOR PRODUCING CONJUGATES THEREOF |
| 摘要 |
The present invention relates to variable domains of a camelid heavy-chain antibodies directed against a phosphorylated tau protein and conjugates thereof. The present invention also relates to the use of these domains or conjugates for treating or diagnosing disorders mediated by neurofibrillary tangles, neuropil threads or dystrophic neurites, such as tauopathies. |
| 申请公布号 |
US2017058022(A1) |
申请公布日期 |
2017.03.02 |
| 申请号 |
US201515114324 |
申请日期 |
2015.01.28 |
| 申请人 |
F. HOFFMANN-LA ROCHE AG ;INSTITUT PASTEUR ;COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES AL TERNATIVES ;CENTRE NATION DE LA RECHERCHE SCIENTIFIQUE (CNRS) |
发明人 |
LAFAYE Pierre;BAY Sylvie;DELATOUR Benoit;DHENAIN Marc;DUYCKAERTS Charles;LI Tengfei;VANDESQUILLE Matthias;CZECH Christian;GRUENINGER Fiona |
| 分类号 |
C07K16/18;A61K49/00;G01N33/68;A61K49/16 |
主分类号 |
C07K16/18 |
| 代理机构 |
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代理人 |
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| 主权项 |
1. An isolated variable domain of a camelid heavy-chain antibody (VHH), characterized in that it is directed against a phosphorylated tau protein and it is obtainable by immunizing a camelid with the single phospho-peptide derived from the C-terminus of a tau protein of sequence CSIDMVDS(PO3H2)PQLATLAD (SEQ ID NO. 6) or a phospho-tau enriched Alzheimer's disease brain extract from a human. |
| 地址 |
Basel CH |
