COMPOSITION AND METHODS FOR HYBRIDIZATION

摘要

The invention relates to a composition for use in hybridization, wherein the composition contains: (a) at least one hybridization probe ("component (a)"); (b) at least one polar protic or polar aprotic solvent ("component (b)") having a cyclic molecular structure; and (c) at least one carboxylic acid amide and/or salts thereof ("component (c)") in an amount of more than 10 vol% with respect to the composition. The invention further relates to the use of said composition and to methods for detecting nucleic acids and/or chromosomal aberrations in a biological sample by means of hybridization by using the composition.