| 发明名称 |
RAPID-ACTING INSULIN COMPOSITIONS |
| 摘要 |
The invention is a pharmaceutical composition of human insulin or insulin analog that includes citrate, treprostinil and stabilizing agents, that has faster pharmacokinetic and/or pharmacodynamic action than commercial formulations of existing insulin analog products and that is stable for commercial use. |
| 申请公布号 |
US2017056478(A1) |
申请公布日期 |
2017.03.02 |
| 申请号 |
US201615241412 |
申请日期 |
2016.08.19 |
| 申请人 |
Eli Lilly and Company |
发明人 |
Akers Michael Patrick;Christe Michael Edward;Hardy Thomas Andrew;Majumdar Ranajoy;Nguyen Chi Arch;Paavola Chad Donald;Sarin Virender Kumar;Schulte Nanette Elizabeth |
| 分类号 |
A61K38/28;A61K47/02;A61K47/10;A61K47/12 |
主分类号 |
A61K38/28 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A pharmaceutical composition comprising:
a. an insulin; b. citrate, in a concentration from about 5 to about 25 mM; c. treprostinil, in a concentration from about 0.04 to about 20 μg/mL; d. zinc, in a concentration sufficient to provide at least 2 zinc ions per six molecules of insulin; e. a preservative; and f. one or more additional stabilizing agents;and having a pH of about 7.0 to about 7.8 at room temperature. |
| 地址 |
Indianapolis IN US |
