| 发明名称 |
METHODS, COMPOSITIONS AND KITS FOR CELL SPECIFIC MODULATION OF TARGET ANTIGENS |
| 摘要 |
The present invention provides, inter alia, a method for cell-specific modulation of a target antigen. The method comprises contacting a target cell having the target antigen on the surface of the target cell with: (a) first multi-specific antigen-binding polypeptide comprising: (i) a cell-specific antigen binding domain (C1), (ii) a target antigen binding domain (T1); and (b) a second multi-specific antigen-binding polypeptide comprising: (i) a cell-specific antigen binding domain (C2), (ii) a target antigen binding domain (T2); wherein C1 and C2 interact with the same cell-specific antigen, and the cell-specific antigen and the target antigen are on the same target cell. Pharmaceutical compositions and kits thereof are also included in the present invention. |
| 申请公布号 |
US2017058045(A1) |
申请公布日期 |
2017.03.02 |
| 申请号 |
US201515119986 |
申请日期 |
2015.02.20 |
| 申请人 |
Regeneron Pharmaceuticals, Inc. |
发明人 |
GROMADA Jesper;SMITH Eric;MURPHY Andrew;PAPADOPOULOS Nicholas;MARTIN Joel;YANCOPOULOS George;MACDONALD Douglas;BUCKLER David |
| 分类号 |
C07K16/32;A61K39/395;C07K16/28 |
主分类号 |
C07K16/32 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for cell-specific modulation of a target antigen comprising contacting a target cell having the target antigen on the surface of the target cell with:
a. a first multi-specific antigen-binding polypeptide comprising:
(i) a cell-specific antigen binding domain (C1) and(ii) a target antigen binding domain (T1); and b. a second multi-specific antigen-binding polypeptide comprising:
(i) a cell-specific antigen binding domain (C2) and(ii) a target antigen binding domain (T2);wherein C1 and C2 interact with the same cell-specific antigen, and the cell-specific antigen and the target antigen are on the same target cell. |
| 地址 |
Tarrytown NY US |
