| 发明名称 |
Process for the preparation of Efavirenz and devices suitable therefore |
| 摘要 |
The invention relates to a process for the preparation of Efavirenz via an efficient transition metal catalyzed cyclization, to a device suitable to perform such process as well as to novel intermediates. |
| 申请公布号 |
US2017057937(A1) |
申请公布日期 |
2017.03.02 |
| 申请号 |
US201514837500 |
申请日期 |
2015.08.27 |
| 申请人 |
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. |
发明人 |
Correia Camille A.;Gilmore Kerry;McQuade David Tyler;Seeberger Peter H. |
| 分类号 |
C07D265/18;B01J19/00;C07C33/50;C07C29/00;C07C29/68;C07C45/00;C07C265/12;C07F1/08 |
主分类号 |
C07D265/18 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A process for the preparation of 6-chloro-4-(2-cyclopropylethynyl)-4-(trifluoromethyl)-1H-3,1-benzoxazin-2-one comprising reacting 4-cyclopropyl-2-(2,5-dichloro-phenyl)-1,1,1-trifluoro-but-3-yn-2-ol with at least one cyanate in the presence of at least one transition metal compound. |
| 地址 |
Munich DE |
