POROUS CALCIUM PHOSPHATE MICROSPHERE MATERIAL HAVING BIG SURFACE HOLES, AND PREPARATION METHOD AND APPLICATIONS

摘要

A porous calcium phosphate microsphere material having big surface holes, and a preparation method thereof and applications thereof. The preparation method comprises the following steps: (1) dissolving polysaccharide gum in deionized water to prepare a polysaccharide gum solution; (2) dissolving a thickener in deionized water to prepare a thickener solution; (3) mixing the polysaccharide gum solution with the thickener solution to obtain a polysaccharide gum/thickener solution; (4) mixing calcium phosphate bone cement powder with the polysaccharide gum/thickener solution to obtain calcium phosphate bone cement slurry; and (5), stirring the calcium phosphate bone cement slurry at a high speed, conducting ultrasonic treatment, dropwise adding the slurry to liquid nitrogen, and conducting curing and vacuum drying on refrigerated microspheres to obtain porous calcium phosphate microspheres having big surface holes.