发明名称 |
PYRIDOPYRIMIDINONE COMPOUNDS FOR MODULATING THE CATALYTIC ACTIVITY OF HISTONE LYSINE DEMETHYLASES (KDMS) |
摘要 |
The present invention provides a compound of formula (I) being capable of modulating the activity of histone lysine demethylase (KDM), pharmaceutical compositions thereof, methods to prepare the said compounds, and the use of such compounds as a medicament. The compound of formula (I) acts as KDM inhibitor with marked potency, thereby having an outstanding potential for a pharmaceutical intervention of cancer and any other diseases related to KDM dysregulation. Formula (I) |
申请公布号 |
WO2017034377(A1) |
申请公布日期 |
2017.03.02 |
申请号 |
WO2016KR09544 |
申请日期 |
2016.08.26 |
申请人 |
DONG-A ST CO., LTD. |
发明人 |
KIM, Myeong-Seop;PARK, Taesun;YOON, Taeyoung;YANG, Seung Min;KIM, Hae-Sun;KIM, Jun Gyu |
分类号 |
C07D471/04;A61K31/4375;A61K31/519;C07D487/04 |
主分类号 |
C07D471/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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