| 主权项 |
1. An imaging agent comprising a compound of Formula I,or a pharmaceutically acceptable salt thereof, wherein
m is 0, 1, or 2; n is 1 or 2; J is C(═O) or —CH2—; X is S or N; Y is CH or N; Z is CH or N; W is N or S; for each occurrence, R1 is independently chosen from halo, lower alkoxy, hydroxy, aryl, heteroaryl, cycloalkoxy, or lower alkyl, wherein the lower alkoxy, cycloalkoxy, lower alkyl, aryl, or heteroaryl are each optionally substituted with one, two, or three groups independently selected from lower alkoxy, alkenyl, —NR4R5, halo, or heteroaryl optionally substituted with one to three lower alkoxy; R2 is hydrogen or lower alkyl; and R3 is alkyl, aryl, aralkyl, heterocycloalkyl, heterocycloalkenyl, heteroaryl, or heteroaralkyl, each of which is optionally substituted with one, two, or three groups independently chosen from hydroxy, lower alkoxy optionally substituted with lower alkoxy or halo, lower alkyl optionally substituted with halo, halo, heteroaryl, —(CH2)tNR4R5, oxo, cyano, or —C(O)—NR4R5, or R2 and R3 taken together with the nitrogen to which they are bound form a heterocycloalkyl ring, optionally substituted with one, two, or three groups independently chosen from hydroxy, lower alkoxy, lower alkyl, halo, or —C(O)—NR4R5; t is 0, 1, or 2; each R4 is independently chosen from hydrogen or lower alkyl; each R5 is independently chosen from hydrogen or lower alkyl; or R4 and R5 taken together with the nitrogen to which they are bound form a heterocycloalkyl ring, optionally substituted with one, two, or three groups independently chosen from hydroxy, lower alkoxy, lower alkyl, halo, or —C(O)—NR6R7; each R6 is independently chosen from hydrogen or lower alkyl; and each R7 is independently chosen from hydrogen or lower alkyl; wherein the compound of Formula I, or a pharmaceutically acceptable salt thereof, is labeled with one or more positron-emitting radionuclides. |
