CHEMICALLY MODIFIED QUINOLINE AND QUINOLONE DERIVATIVES USEFUL AS CB-1 INVERSE AGONISTS

摘要

Disclosed are compounds, compositions and methods for treating of disorders that are affected by the modulation of the CB1 receptor. Such compounds are represented by Formula (I);wherein R1, R2, R3, L1, n, v, r, w, and g are defined herein.

and further represented by Formula (II)
;wherein the group “X═Y”, ring A, R10, R11, R30, W, and t are defined herein.

主权项

1. A compound of Formula (I) wherein
R1 and R2 are selected from the group consisting of i) hydrogen, such that one of R1 and R2 is hydrogen in every instance;
R3 is a substituent selected from the group consisting of methyl, C1-4alkoxycarbonylamino-ethyl, C1-4alkoxycarbonyl-ethyl, carboxyethyl, aminoethyl, hydrogen, 4-hydroxymethylphenyl, or a substituent selected from the group consisting of wherein L1 is selected from n is an integer from 2 to 36; v is an integer from 1 to 12; r is an integer from 2 to 7; w is an integer from 1 to 24; g is an integer from 1 to 24; or an enantiomer, diastereomer, or pharmaceutically acceptable salt form thereof.