SKIN-PROTECTION COMPOSITION CONTAINING DENDROBIUM-BASED INGREDIENTS

摘要

A skin-protection composition is shown that comprises stilbenoid(s) and/or stilbenoid-containing extract(s) obtained from Dendrobium plants, such as Dendrobium officinale and Dendrobium nobile for the management of melanogenesis, skin-darkening and skin-aging. More particularly, the usage of Dendrobium ingredients and stilbenoids is shown to reduce the formation of melanin in melanocytes. The usage of Dendrobium ingredients and stilbenoids is also shown to reduce the generation of reactive oxygen species and oxidative free radicals. The use of Dendrobium-derived extracts or ingredients or stilbenoids is shown in the formulation of skin-protection, skin-whitening and/or anti-skin aging products.

主权项

1. A compound comprising formula (4):wherein
R2, R4, and R8 are each independently selected from —OR11, —OCH2R12, —OC(O)R11, —OCH2C(O)OR12 and —OC(O)CH2R12; R1, R3, R5, R6, R7, R9 and R10 are each independently selected from hydrogen, halogen, trifluoromethyl, —OR12 and —OC(O)R12; or R2 and R3, or R7 and R8 may be taken together with the carbon atoms to which they are attached to form a cyclic group; R11 is independently selected from —(CH2)-hydrocarbyl, C2-10 alkyl, alkenyl and heterocyclyl. Each of these groups is optionally substituted with 1, 2, 3, 4 or 5 R13; R12 is independently selected from hydrocarbyl and heterocyclyl, either of which is optionally substituted with 1, 2, 3, 4 or 5 R13; R13 is independently selected from halogen, trifluoromethyl, cyano, nitro, oxo, —OR14, —C(O)R15, —C(O)N(R14)R15, —C(O)OR14, —OC(O)R15, —S(O)2R14, —S(O)2N(R14)R15, —N(R14)R15; R14 and R15 are each independently hydrogen or selected from hydrocarbyl and heterocyclyl, either of which is optionally substituted with 1, 2, 3, 4 or 5 substituents independently selected from halogen, cyano, amino, hydroxy, C1-6 alkyl and C1-6 alkoxy; or an enantiomer thereof; or a pharmaceutically acceptable salt or prodrug thereof.