发明名称 Method of Treating Protozoal Gastrointestinal Disorders in Immunocompromised Patients
摘要 The invention relates to a method for treating protozoal gastrointestinal disorders in immunocompromised patients. It includes a method for the isolation of a factor from the milk of hyperimmunized animals in a substantially pure form, and to the use of said factor in combination with vitamins and minerals.
申请公布号 US2017056497(A1) 申请公布日期 2017.03.02
申请号 US201615253733 申请日期 2016.08.31
申请人 Whelihan Joseph;Eley Jada 发明人 Whelihan Joseph;Eley Jada
分类号 A61K39/395;C07K16/12;A61K39/085;A61K39/09;A61K39/02;A61K39/108;A61K39/104;A61K39/112;A61K39/102;A61K31/51;A61K31/525;A61K31/4415;A61K31/714;A61K31/519;A61K31/593;A61K31/375;A61K31/355;A61K33/06;A61K33/30;A23C3/02;C07K16/04 主分类号 A61K39/395
代理机构 代理人
主权项 1. A method of treating cryptosporidiosis or isosporiasis in an immunocompromised animal which comprises: administering to said immunocompromised animal a product comprised of a vitamin and mineral blend (Vitamins B1, B2, B6, B12, Folate, D3, C, E, and minerals Magnesium and Zinc), probiotics, including but not limited to Lactobacillus and Bifidobacterium species, mixed with a hyperimmune milk product containing a biologically active component which reduces a number of oocysts in a stool, reduces a number of Cryptosporidia or Isospora parasites in an intestine or alleviates symptoms of cryptosporidiosis or isosporiasis in a subject infected with Cryptosporidia or Isospora from a hyperimmunized milk-producing mammal selected from the group consisting of cows, sheep, and goats, in amounts sufficient to treat said cryptosporidiosis or isosporiasis, wherein said hyperimmune milk product is selected from the group consisting of hyperimmune whole milk, hyperimmune whole milk fractions, and derivatives of hyperimmune whole milk which contain said biologically active component and is prepared by a process comprising: (i) hyperimmunizing said milk-producing mammal with a mixture of non-protozoan bacterial antigens;(ii) collecting milk from said milk-producing mammal after said milk-producing mammal reaches a hyperimmune state;(iii) filtering said milk through a molecular sieve which excludes proteins of molecular weight greater than 100,000 daltons;(iv) blending said filtered milk retentate with the said vitamin and mineral blend and probiotics; and(v) testing the blend of step (iv) for its ability to reduce the number of oocysts in the stool, reduce the number of Cryptosporidia or Isospora parasites in the intestine or alleviate symptoms of cryptosporidiosis or isosporiasis in a subject infected with Cryptosporidia or Isospora by administering to said subject the blend of step (iv) and measuring the reduction of said oocysts, parasites, or symptoms.
地址 Palm Beach Garden FL US