| 摘要 |
The present disclosure relates to certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamide compounds (including pharmaceutically acceptable salts thereof),;;that inhibit dipeptidyl peptidase 1 (DPP1) activity, to their utility in treating and/or preventing clinical conditions including respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), to their use in therapy, to pharmaceutical compositions containing them and to processes for preparing such compounds. |
| 主权项 |
1. A compound of formula (I)wherein
R1 is R2 is selected from hydrogen, F, Cl, Br, OSO2C1-3alkyl, or C1-3alkyl; R3 is selected from hydrogen, F, Cl, Br, CN, CF3, SO2C1-3alkyl, CONH2 or SO2NR4R5, wherein R4 and R5 together with the nitrogen atom to which they are attached form a azetidine, pyrrolidine or piperidine ring; orR1 is selected from X is selected from O, S or CF2; Y is selected from O or S; Q is selected from CH or N; R6 is selected from C1-3alkyl, wherein said C1-3alkyl is optionally substituted by 1, 2 or 3 F and optionally by one substituent selected from OH, OC1-3alkyl, N(C1-3alkyl)2, cyclopropyl, or tetrapydropyran; R7 is selected from hydrogen, F, Cl or CH3; or a pharmaceutically-acceptable salt thereof. |
