发明名称 |
METHODS FOR DETECTING PHOSPHORYLATED ALPHA-SYNUCLEIN |
摘要 |
The invention provides methods of detecting alpha-synuclein using a capture antibody and a reporter antibody. The capture antibody binds preferentially to full-length alpha- synuclein phosphorylated at residue 129 (PS129 alpha-synuclein) over unphosphorylated full- length alpha-synuclein. The 11A5 antibody is an example of a suitable capture antibody. The reporter antibody binds to an epitope within residues 40-55 of alpha-synuclein. The 23E8 antibody is an example of such an antibody. Because only a small proportion of alpha-synuclein is phosphorylated high sensitivity of detection below picomolar is advantageous. |
申请公布号 |
WO2017033152(A1) |
申请公布日期 |
2017.03.02 |
申请号 |
WO2016IB55088 |
申请日期 |
2016.08.25 |
申请人 |
PROTHENA BIOSCIENCES LIMITED |
发明人 |
BARBOUR, Robin;ZIESKE, Lynn R. |
分类号 |
G01N33/50;A61K39/395;C07K16/18;C07K16/24;G01N33/58 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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